For an oocyte to get ready for fertilization and expansion into an embryo, the right set of genes has to be turned on. Namekawa suspected this pre-programming with the oocyte genome takes place in several phases — the very first one particular starting off around the time a woman is born. He believed that chromatin remodeling proteins did Substantially of this do the job, by shifting spools all over.
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This might enable clarify why more mature Ladies are more likely to bear little ones with chromosomal Problems like Down Syndrome, through which an extra copy of chromosome 21 finds its way into an oocyte — and later on, an embryo.
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“The Firm of chromatin influences which genes can be expressed,” suggests Namekawa. That’s due to the fact the specific areas of the spools, plus the spacing amongst them, establishes which stretches of DNA could be accessed by molecules termed transcription aspects, which latch on to genes and switch them on.
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